Biochemistry Mnemonics Collection Part-1

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Biochemistry Mnemonics for Medical Students This is part of best medical biochemistry mnemonics including amino acid mnemonics .These mnemonics are collected from various offline and online sources including text books.If you know any other biochemistry  mnemonics please share via comments.

 Essential amino acids PVT. TIM HALL:
Phe
Val
Thr
Trp
Ile
Met
His
Arg
Leu
Lys
· Pvt. is short for Private in the military.
· Arg and His are considered semiessential.
· Alternatively: "MATT VIL PHLy".



 TCA cycle substrates "Citrate Is Krebs' Starting Substrate For Making Oxaloacetate"
Citrate, Isocitrate, alpha-Ketoglutarate, Succinyl-CoA, Succinate, Fumarate, Malate, Oxaloacetate

 Start and stop codonsAUG inAUGurates transcription
 UGA = U Go Away UAA = U Are Away UAG = U Are Gone

Functions of Glutathione "T. M.E.D.I.C.S"
Transport of amino acids
Methemoglobin reduction
Erythrocyte homeostasis (inactivation of free radicals inside RBC)
Detoxification of organophosphorus, halogenated or nitrogenous compounds
Insulin Inactivation
Coenzyme in Reduction reactions
Scavanger of toxic substances


 Catabolism steps of branched chain amino acids "Truck
hit the Ox to Death":
Transamination
Oxidative decarboxylation
Dehydrogenation

 Glycolysis enzymes "High Profile People
 Act Too Glamorous, Picture Posing Every
 Place":
 Hexokinase
 Phosphoglucose isomerase
 Phosphofructokinase (PFK)
 Aldase A
 Triose phosphate isomerase
 Glyceraldehyde-3-phosphate dehydrogenase
 Phosphoglycerate mutase
 Enolase
 Pyruvate kinase

 Fasting state: branched-chain amino acids used by skeletal muscles
"Muscles LIVe fast":
Leucine
Isoleucine
Valine



 Creatine phosphate: amino acid precursors "Nice GAMs!":
Glycine
Arginine
Methionine
· Gam is slang for a person's leg, especiallay an attractive female's leg: "Nice
gams = nice legs!"
 
Trinucleotide repeat disorders"Try hunting for my fried eggs"
Trinucleotide: Huntington's (CAG) MyoTonic dystrophy (CTG) Friedrich's Ataxia (GAA) fraGile X syndrome (CGG)
 


 Fabry disease: presentation FABRY:
 Ferile episodes
 Angiokeratomas/ Alpha galactosidase A deficiency
 Burning pain
 Renal failure
 Youth death


 Porphyrias: acute intermittent porphyria symptoms 5 P's:
 Pain in abdomen
 Polyneuropathy
 Psychologial abnormalities
 Pink urine
 Precipitated by drugs (eg barbiturates, oral contraceptives, sulpha
 drugs)

 BUN:creatinine elevation: causes ABCD:
 Azotremia (pre-renal)
 Bleeding (GI)
 Catabolic status
 Diet (high protein parenteral nutrition)

 G6PD: oxidant drugs inducing hemolytic anemia AAA:
 Antibiotic (eg: sufamethoxazole)
 Antimalarial (eg: primaquine)
 Antipyretics (eg: acetanilid, but not aspirin or acetaminophen)

 Vitamin B3 (niacin, nicotinic acid) deficiency: pellagra The
 3 D's of pellagra:
 Dermatitis
 Diarrhea
 Dementia
 · Note vitamin B3 is the 3D's.

 Glycogen storage: Anderson's (IV) vs. Cori's (III) enzyme defect
 ABCD:
 Anderson's=Branching enzyme.
 Cori's=Debranching enzyme.
 · Otherwise, can't really distinguish clinically.

 Benzene ring: effects of substituents on further additions
 "Benzene likes to ROMP. We HOPED she's be safe, but now she's
 knocked up. ADOPt or WEDD'M?":
 ROMP: Substituents in order: R-group, Ortho, Meta,
 Para.
 HOPED: Halogens are Ortho, Para, Electron
 withdrawing, Deactivating.
 ADOPt: Addititive substituents Direct Ortho & Para.
 WEDD'M: Withdrawing Electrons Deactivates, Directs
 Meta.

 Cathode: what happens during electrolysis Current 
 Carries Cations to the Cathode for reduCtion.

 Cis/trans (geometric) isomer nomenclature 
The letter "Z" is
 written in a zigzag way. If you draw a vertical line splitting it down the
 middle then its the same halves (same sides of double bond). The letter "E" is
 written differently so a vertical line splits it into different halves
 (different sides of double bond).

 Cis/trans (geometric) isomers: arrangement of functional groups
 Cis starts with a C and the functional groups form a C.
 Trans, therefore is the other one by default.



 Pompe's disease: type "Police = Po + lys":
 Pompe's disease is a lysosomal storage disease (alpha 1,4
 glucosidase).

 Golgi complex: functions "Golgi Distributes A SPAM":
 Distributes proteins and lipids from ER
 Add mannose onto specific lysosome proteins
 Sulfation of sugars and slected tyrosine
 Proteoglycan assembly
 Add O-oligosugars to serine and threnonine
 Modify N-ologosugars on asparagine

 Dicarboxylic acids (alpha, omega) C2 through C10: common names
 "Oh My, Such Good Apple Pie, Sweet
 As Sugar!":
 Oxalic
 Malonic
 Succinic
 Glutaric
 Adipic
 Pimelic
 Suberic
 Azelaic
 Sebacic


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