COMMON CHEMOTHERAPY DRUGS

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COMMON CHEMOTHERAPY DRUGS


DRUG
CLASS
TARGET
ORGAN TOXICITY
OTHER SIDE EFFECTS
INTERVENTIONS
CELL CYCLE SPECIFIC
methotrexate
ANTIMETABOLITE
folic acid, pyrimidine, purine
hepatotoxic
nephrotoxic
photosensitivity
acute tumor lysis syndrome
administer leucovorin to stop cell lysis
administer allopurinol for uric acid from cell lysis
fluorouracil
cardiotoxic
vincristine
VINCA ALKALOID
M phase
neurotoxic
peripheral neuropathy
(esp. foot drop)
hyponatremia
constipation
increase fluid intake
adequate sodium diet
prevent foot drop
paclitaxel
TAXANE
M phase
none
anaphylaxis
skin test
premedicate with steroids, antihistamines, H2 blockers
irinotecan
AND
topotecan
TOPOISOMERASE I INHIBITOR
S phase
none
severe diarrhea
administer loperamide OR atropine for severe diarrhea
etoposide
TOPOISOMERASE II INHIBITOR
none
hypotension
monitor BP closely
NON-CELL CYCLE SPECIFIC
cyclophosphamide
ALKYLATING AGENTS
DNA structure
nephrotoxic
hemorrhagic cystitis
sterility
administer early in the morning
increase oral fluid intake
assess urine for blood
void frequently especially before bed
cisplatin
nephrotoxic
ototoxic
highly emetogenic
peripheral neuropathy
Mg & K imbalances
administer 5-HT3 antagonists for emesis
monitor I/O, creatinine, and BUN
increase oral fluid intake
administer mannitol
doxorubicin
ANTIBIOTICS
cardiotoxic
red-colored urine
HepB reactivation
monitor ECG and echocardiograms
bleomycin
pulmotoxic
anaphylaxis
skin test
assess lung sounds from time to time
tamoxifen
ANTIESTROGEN
estrogen receptors
hepatotoxic
deep vein thrombosis
decreased libido
steatorrhea
monitor liver enzymes
decreased fat intake
asparaginase
OTHERS
amino acid asparagine
pancreatitis
anaphylaxis
skin test
hydroxyurea
DNA and RNA structure
hepatotoxic
nephrotoxic
acute myeloid leukemia
monitor I/O, creatinine, and BUN, liver enzymes

COMMON TUMOR MARKERS
alpha fetoprotein (AFP) - liver cancer

bladder tumor antigen (BTA) - bladder cancer

CA 15-3 - breast cancer

CA 125 - ovarian cancer

calcitonin - thyroid cancer
carcinoembryonic antigen (CEA) - colon cancer

estrogen/progesterone receptors - breast cancer

human chorionic gonadotropin (HCG) - choriocarcinoma

prostate specific antigen - prostate cancer


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notes.nursium.com: COMMON CHEMOTHERAPY DRUGS
COMMON CHEMOTHERAPY DRUGS
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https://notes.nursium.com/2017/03/common-chemotherapy-drugs.html
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