Beta blockers with intrinsic sympathomimetic activity Picture diabetic and asthmatic kids riding away on a cart that rolls on pinwheels. Pindolol and Carteolol have high and moderate ISA respectively, making them acceptable for use in some diabetics or asthmatics despite the fact that they are non-seletive beta blockers.
Amiodarone: action, side effects 6 P’s:
Prolongs action potential duration
Pigmentation of skin
Pulmonary alveolitis and fibrosis Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism
Morphine: effects MORPHINES:
Pain supression Histamine release/ Hormonal alterations Increased ICT
Monoamine oxidase inhibitors:
members \”PIT of despair\”: Phenelzine
· A pit of despair, since MAOs treat depression.
Antimuscarinics: members, action \”Inhibits Parasympathetic And Sweat\”:
· Muscarinic receptors at all
parasympathetic endings sweat glands
Patent ductus arteriosus: treatment \”Come In and Close the door\”:
INdomethacin is used to ClosePDA.
Etoposide: action, indications, side effect \”eTOPoside\”:
· Action: Inhibits TOPoisomerase II · Indications:
Oat cell carcinoma of lung
Prostate carcinoma · Side effect:
Affects TOP of your head, causing alopecia
Antibiotics contraindicated during pregnancy MCAT: Metronidazole
Lithium: side effects LITHIUM:
Leukocytes Increased (leukocytosis)
Moms beware (teratogenic)
Quinolones [and Fluoroquinolones]:
mechanism \”Topple the Queen\”: Quinolone interferes with Topoisomerase II.
MPTP: mechanism, effect MPTP: Mitochondrial Parkinson’sType Poison. · A mitochondrial poison that elicits a Parkinson’s-type effect.
Osmotic diuretics: members GUM:
Sulfonamide: major side effects · Sulfonamide side effects:
Solubility low (causes crystalluria) Serum albumin displaced (causes
newborn kernicterus and potentiation of other serum albumin-binders like warfarin)