Lupus: drugs inducing it HIP:
RTI: drugs to treat viral respiratory infections "You'd get a respiratory infection if you shoot an ARO (arrow) laced with viruses into the lungs": ARO:
Medication administration: short checklist TRAMP: · Before dispensing medication, ensure have correct: Time
Opiates: overdose findings "Cool to the touch, unresponsive to pain,
Hunger diminished, and scars over vein.
Pupils pinpointed, and blood pressure low,
Urine diminished, and breathing is slow."
Lithium: side effects LITH:
Insipidus [diabetes insipidus, tied to polyuria] Tremor/ Teratogenesis Hypothyroidism
SSRIs: side effects SSRI: Serotonin syndrome
Reproductive disfunctions in male Insomnia
Metabolism enzyme inducers "Randy's Black Car
Goes Putt Putt and Smokes":
Phenobarbitone: side effects Children are annoying (hyperkinesia, irritability, insomnia, aggression). Adults are dosy (sedation, dizziness, drowsiness).
Cholinergics (eg organophosphates): effects If you know these, you will be "LESS DUMB": Lacrimation
Excitation of nicotinic synapses
Routes of entry: most rapid ways meds/toxins enter body "Stick it, Sniff it, Suck it, Soak it": Stick = Injection
Sniff = inhalation
Suck = ingestion
Soak = absorption
Hepatic necrosis: drugs causing focal to massive necrosis "Very Angry Hepatocytes":
Acetaminophen Halothane Warfarin: action, monitoring WePT: Warfarin works on the extrinsic pathway and is monitored by PT.
Beta-blockers: side effects "BBC Loses Viewers In Rochedale":
Vivid dreams & nightmares
-ve Inotropic action
Reduced sensitivity to hypoglycaemia
Zero order kinetics drugs (most common ones) "PEAZ
(sounds like pees) out a constant amount": Phenytoin
Zero order · Someone that pees out a constant amount describes zero order kinetics (always the same amount out)
Benzodiazepines: actions "Ben SCAMs Pam into seduction not by brain but by muscle": Sedation anti-Convulsant anti-Anxiety
Not by brain: No antipsychotic activity.
Beta-1 vs Beta-2 receptor location "You have 1 heart and 2 lungs": Beta-1 are therefore primarily on heart.
Beta-2 primarily on lungs.
Cisplatin: major side effect, action "Ci-Splat-In": Major side effect: Splat (vomiting sound)--vomiting so severe that anti-nausea drug needed.
Action: Goes Into the DNA strand.
Pupils in overdose: morphine vs. amphetamine "MorPHINE: Fine. AmPHETamine: Fat": Morphine overdose: pupils constricted
Amphetamine overdose: pupils dilated
Atropine use: tachycardia or bradycardia "A goes with
B": Atropine used clinically to treat Bradycardia.
Reserpine action Reserpine depletes the
Reserves of catecholamines [and serotonin].
Botulism toxin: action, related bungarotoxin Action: "Botulism
Bottles up the Ach so it can't be the released": Related bungarotoxin: "Botulism is related to Beta Bungarotoxin (beta-, not alpha-bungarotoxin--alpha has different mechanism).
Ipratropium: action Atropine is buried in the middle: iprAtropium, so it behaves like Atropine.
Bleomycin: action "BleoMycin Blows My DNA to bits": Bleomycin works by fragmenting DNA
(blowing it to bits). MyDNA signals that its used for cancer (targeting self cells).
Propranolol and related '-olol' drugs: usage "olol" is just two backwards lower case b's. Backward b's stand for "beta blocker". · Beta blockers include acebutolol, betaxolol, bisoprolol, oxprenolol, propranolol.
Succinylcholine: action, use Succinylcholine gets Stuck to Ach receptor, then Sucks ions in through open pore. You Suck stuff in through a mouthtube, and drug is used for intubation.
Corticosteroids: adverse side effects CUSHINGS BAD MD:
Up all night (sleep disturbances)
Suppression of HPA axis
Hypertension/ buffalo Hump
Bone loss (osteoporosis) Acne
Myopathy, moon faces
Depression and emotional changes
Busulfan: features ABCDEF: Alkylating agent
Bone marrow suppression s/e
Dark skin (hyperpigmentation) s/e
Endrocrine insufficiency (adrenal) s/e Fibrosis (pulmonary) s/e