Pharmacology Mnemonics part 5

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Pharmacology Mnemonics



Propythiouracil (PTU): mechanism It inhibits PTU:
Peroxidase/ Peripheral deiodination
Tyrosine iodination

Union (coupling)


Enoxaprin (prototype low molecular weight heparin): action, monitoring

EnoXaprin only acts on factor Xa. Monitor Xa concentration, rather than APTT.


Beta-blockers: nonselective betablockers "Tim Pinches His Nasal Problem" (because he has a runny nose...):

Timolol
Pindolol
Hismolol
Naldolol
Propranolol


Nicotinic effects MTWTF (days of week):
Mydriasis/ Muscle cramps
Tachycardia
Weakness
Twitching
Hypertension/ Hyperglycemia

Fasiculation


Muscarinic effects SLUG BAM:
Salivation/ Secretions/ Sweating
Lacrimation
Urination
Gastrointestinal upset

Bradycardia/ Bronchoconstriction/ Bowel movement
Abdominal cramps/ Anorexia

Miosis


Phenytoin: adverse effects PHENYTOIN:

P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
Yellow-browning of skin
Teratogenicity
Osteomalacia
Interference with B12 metabolism
(hence anemia)
Neuropathies: vertigo, ataxia, headache 






Gynaecomastia-causing drugs DISCOS:

Digoxin
Isoniazid
Spironolactone
Cimetidine
Oestrogens
Stilboestrol


Hypertension: treatment ABCD:
ACE inhibitors/ AngII antagonists (sometimes Alpha agonists also)

Beta blockers
Calcium antagonists

Diuretics (sometimes vasoDilators also)


Diuretics classification in order of site of action "COLTPee:"
In their sequential site of action along the nephron:

Carbonic anhydrase inhibitors (at the proximal tubule)
Osmotic diuretics (at the Loop of Henle)
Loop diuretics (at the ascending loop)
Thiazides (at the distal tubule)

Potassium-sparing diuretics (at the collecting tubules) ·

Diuretics make patient pee like a horse, hence "Colt Pee".



Clopidogrel: use CLOPIdogrel is a drug that prevents
CLots, an Oral Platelet Inhibitor (OPI).


Teratogenic drugs: major nonantibiotics TAP CAP:

Thalidomide
Androgens
Progestins
Corticosteroids
Aspirin & indomethacin

Phenytoin


Physostigmine vs. neostigmine LMNOP:
Lipid soluble
Miotic
Natural
Orally absorbed well

Physostigmine
Neostigmine, on the contrary, is:
Water soluble
Used in myesthenia gravis
Synthetic
Poor oral absorption


Prazocin usage Prazocin sounds like an acronym of "praszz zour urine". Therefore Prazocin used for urinary retention in BPH.


Steroid side effects CUSHINGOID:
Cataracts
Ulcers
Skin: striae, thinning, bruising

Hypertension/ Hirsutism/ Hyperglycemia
Infections

Necrosis, avascular necrosis of the femoral head

Glycosuria
Osteoporosis, obesity
Immunosuppression

Diabetes


Beta blockers with CYP2D6 polymorphic metabolism "I Met Tim Carver, the metabolic polymorph": · The following beta blockers require dose adjustment due to CYP2D6 polymorphic metabolism:

Metoprolol

Timolol
Carvedilol (in patients with lower or higher than normal CYP2D6 activity)

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Pharmacology Mnemonics part 5
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