Pharmacology Mnemonics
Propythiouracil (PTU): mechanism It inhibits PTU:
Peroxidase/ Peripheral
deiodination
Tyrosine iodination
Union (coupling)
Union (coupling)
Enoxaprin (prototype low molecular weight heparin): action, monitoring
EnoXaprin only acts on factor Xa. Monitor Xa concentration, rather than APTT.
EnoXaprin only acts on factor Xa. Monitor Xa concentration, rather than APTT.
Beta-blockers: nonselective betablockers "Tim Pinches His Nasal Problem"
(because he has a runny nose...):
Timolol
Timolol
Pindolol
Hismolol
Naldolol
Propranolol
Nicotinic effects MTWTF
(days of week):
Mydriasis/ Muscle cramps
Tachycardia
Weakness
Twitching
Hypertension/ Hyperglycemia
Fasiculation
Fasiculation
Muscarinic effects SLUG BAM:
Salivation/ Secretions/ Sweating
Lacrimation
Urination
Gastrointestinal upset
Bradycardia/ Bronchoconstriction/ Bowel movement
Bradycardia/ Bronchoconstriction/ Bowel movement
Abdominal cramps/ Anorexia
Miosis
Miosis
Phenytoin: adverse effects PHENYTOIN:
P-450 interactions
P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
Yellow-browning of skin
Teratogenicity
Osteomalacia
Interference with B12 metabolism
(hence anemia)
Neuropathies: vertigo, ataxia, headache
Gynaecomastia-causing drugs DISCOS:
Digoxin
Gynaecomastia-causing drugs DISCOS:
Digoxin
Isoniazid
Spironolactone
Cimetidine
Oestrogens
Stilboestrol
Hypertension: treatment ABCD:
ACE inhibitors/ AngII
antagonists (sometimes Alpha
agonists also)
Beta blockers
Beta blockers
Calcium antagonists
Diuretics (sometimes vasoDilators also)
Diuretics (sometimes vasoDilators also)
Diuretics classification in order of site of action "COLTPee:"
In their sequential site of action
along the nephron:
Carbonic anhydrase inhibitors (at the proximal tubule)
Carbonic anhydrase inhibitors (at the proximal tubule)
Osmotic diuretics (at the Loop of Henle)
Loop diuretics (at the ascending loop)
Thiazides (at the distal tubule)
Potassium-sparing diuretics (at the collecting tubules) ·
Diuretics make patient pee like a horse, hence "Colt Pee".
Potassium-sparing diuretics (at the collecting tubules) ·
Diuretics make patient pee like a horse, hence "Colt Pee".
Clopidogrel: use CLOPIdogrel
is a drug that prevents
CLots, an Oral Platelet Inhibitor (OPI).
Teratogenic drugs: major nonantibiotics TAP CAP:
Thalidomide
Thalidomide
Androgens
Progestins
Corticosteroids
Aspirin & indomethacin
Phenytoin
Phenytoin
Physostigmine vs. neostigmine LMNOP:
Lipid soluble
Miotic
Natural
Orally absorbed well
Physostigmine
Physostigmine
Neostigmine, on the contrary, is:
Water soluble
Used in myesthenia gravis
Synthetic
Poor oral absorption
Prazocin usage Prazocin sounds like an acronym of "praszz zour
urine". Therefore Prazocin used for urinary retention in BPH.
Steroid side effects CUSHINGOID:
Cataracts
Ulcers
Skin: striae, thinning, bruising
Hypertension/ Hirsutism/ Hyperglycemia
Hypertension/ Hirsutism/ Hyperglycemia
Infections
Necrosis, avascular necrosis of the femoral head
Glycosuria
Necrosis, avascular necrosis of the femoral head
Glycosuria
Osteoporosis, obesity
Immunosuppression
Diabetes
Diabetes
Beta blockers with CYP2D6 polymorphic metabolism "I Met Tim Carver, the metabolic
polymorph": · The following beta blockers require dose adjustment due to
CYP2D6 polymorphic metabolism:
Metoprolol
Timolol
Metoprolol
Timolol
Carvedilol (in patients with lower or higher than normal CYP2D6
activity)
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