Drugs in blood Disorders easy to remember chart

Drugs			MOA	Indications	PTT	PT	TT	Bleed- Time
A N T I C O A G U L A N T S	Heparin Antidote: Protamine Sulfate		Activates ATIII (Antithrombin) =/=> IIa (Thrombin) and Xa. Short t1/2, High MW = safe in pregnancy.	Acute Management: * PE * Acute Coronary Sd *DVT *MI	↑	_	↑	_
	Low MW Heparin: Enoxaparin, Dalteparin		Act > on Xa. No monitoring needed t1/2 = 2-4x longer
	Warfarin Antidotes: Vit K, Fresh Frozen Plasma		=/=> Vit K epoxide reductase =/=> gamma carboxilation => â†“Vit K synthesis = ↓II, VII, IX, X, Prot C, Prot S Liposoluble, CI in pregnancy, Control INR	Chronic Management: *After STEMI Prophylaxis: *Venous thromboembolism *Stroke: A.fib	_	↑	↑	_
	Lepirudin Bivalirudin Argatroban Dabigatran		Hirudin derivatives Direct thrombin inhibitors	*HIT * Bivalirudin + ASA: Percutaneous Transluminal Coronary Angioplasty (PTCA)	<	<	↑	_
	ApiXaban RibaroXaban IdrapararinuX Ultralow MWH		Binds and directly inhibits Xa	Tx & Prophylaxis: *PE *DVT Prophylaxis: * Stroke: A.fib	↑	↑	_	_
THROMBO LYTICS	tPA: Alteplase rPA: Reteplase TNK-tPA: Tenecteplase APSAC: Anistreplase Antidotes: Aminocaproic Acid, Tranexemic Acid		Converts plasminogen Ã  plasmin. Plasmin degrades Thombin & Fibrin (into Fibrin Degradation Products)	*Early MI *Early Ischemic Stroke *Thrombolysis of severe PE	↑	↑	_	_
ANTI PLATELETS	Chronic	ASA	Irreversible COX inhibitor	Antiplatelet aggregation	_	_	_	↑
		Clopidogrel Ticlopidine Pasugrel Ticagrelor	=/=> ADP receptors (P2Y12) No fibrinogen binding bc of =/=> IIb/IIIa No platelet aggregation	* Acute Coronary Sd *Coronary Stenting
	Acute	Abciximab Eptifibatide Tirofiban	Antagonist of fibrinogen Receptor: IIb/IIIa = No platelet aggregation	*Unstable angina *PTCA
		Cilostazol Dipyridamole	Phosphodiesterase III inhibitor ↑cAMP in platelets = No platelet aggreg.	*Intermittent claudication *Coronary VD *Stroke, TIA prevention (+ASA) *Angina prevention