Drugs in blood Disorders easy to remember chart

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Drugs
MOA
Indications
PTT
PT
TT
Bleed- Time


A
N
T
I
C
O
A
G
U
L
A
N
T
S
Heparin
Antidote: Protamine Sulfate
Activates ATIII (Antithrombin) =/=> IIa (Thrombin) and Xa.
Short t1/2, High MW = safe in pregnancy.
Acute Management:
* PE
* Acute Coronary Sd
*DVT
*MI

↑

_

↑

_
Low MW Heparin: Enoxaparin, Dalteparin
Act > on Xa. No monitoring needed
t1/2 = 2-4x longer

Warfarin
Antidotes: Vit K,
Fresh Frozen Plasma
=/=> Vit K epoxide reductase
=/=> gamma carboxilation
=> â†“Vit K synthesis
= ↓II, VII, IX, X, Prot C, Prot S
Liposoluble, CI in pregnancy, Control INR
Chronic Management:
*After STEMI
Prophylaxis:
*Venous thromboembolism
*Stroke: A.fib

_

↑

↑

_
Lepirudin
Bivalirudin
Argatroban
Dabigatran

Hirudin derivatives
Direct thrombin inhibitors
*HIT
* Bivalirudin + ASA:
Percutaneous Transluminal
Coronary Angioplasty (PTCA)

<

<

↑

_
ApiXaban
RibaroXaban
IdrapararinuX
Ultralow MWH

Binds and directly inhibits Xa
Tx & Prophylaxis:
*PE *DVT
Prophylaxis:
* Stroke: A.fib

↑

↑

_

_


THROMBO
LYTICS
tPA: Alteplase
rPA: Reteplase
TNK-tPA: Tenecteplase
APSAC: Anistreplase
Antidotes: Aminocaproic Acid, Tranexemic Acid

Converts plasminogen Ã  plasmin.
Plasmin degrades Thombin & Fibrin
(into Fibrin Degradation Products)

*Early MI
*Early Ischemic Stroke
*Thrombolysis of severe PE

↑

↑

_

_





ANTI
PLATELETS

Chronic
ASA
Irreversible COX inhibitor
Antiplatelet aggregation





_





_





_





↑
Clopidogrel
Ticlopidine
Pasugrel
Ticagrelor
=/=> ADP receptors (P2Y12)
No fibrinogen binding bc of =/=> IIb/IIIa
No platelet aggregation

* Acute Coronary Sd
*Coronary Stenting



Acute
Abciximab
Eptifibatide
Tirofiban
Antagonist of fibrinogen Receptor: IIb/IIIa = No platelet aggregation
*Unstable angina
*PTCA

Cilostazol
Dipyridamole

Phosphodiesterase III inhibitor
↑cAMP in platelets = No platelet aggreg.
*Intermittent claudication
*Coronary VD
*Stroke, TIA prevention (+ASA)
*Angina prevention



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notes.nursium.com: Drugs in blood Disorders easy to remember chart
Drugs in blood Disorders easy to remember chart
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